Integrin αII b tail distal of GFFKR participates in inside-out αII b β3 activation.

ABSTRACT:

Background

Increases in ligand binding to integrins (activation) play critical roles in platelet and leukocyte function. Integrin activation requires talin and kindlin binding to integrin β cytoplasmic tails. Research has focused on the conserved GFFKR motif in integrin αII b tails, integrin β cytoplasmic tails and the binding partners of β tails. However, the roles of αII b tail distal of GFFKR motif are unexplored.

Objective

To investigate the role of αII b tail distal of GFFKR in talin-mediated inside-out integrin signaling.

Methods

We used model cell systems to examine the role of αII b tail distal of GFFKR in bidirectional αII b β3 signaling and αII b β3 -talin interactions.

Results

Deletion of amino acid residues after the GFFKR motif in αII b tail modera

SUBMITTER: Li A 

PROVIDER: S-EPMC4107134 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature