Central venous catheter-related thrombosis and thromboprophylaxis in children: a systematic review and meta-analysis.

ABSTRACT:

Objectives

In preparation for a pediatric randomized controlled trial on thromboprophylaxis, we determined the frequency of catheter-related thrombosis in children. We also systematically reviewed the pediatric trials on thromboprophylaxis to evaluate its efficacy and to identify possible pitfalls in the conduct of these trials.

Patients/methods

We searched MEDLINE, EMBASE, Web of Science and the Cochrane Central Register for Controlled Trials for articles published until December 2013. We included cohort studies and trials on patients aged 0-18 years with central venous catheters who underwent active surveillance for thrombosis with radiologic imaging. We estimated the pooled frequency of thrombosis and the pooled risk ratio (RR) with thromboprophylaxis by using a random ef

SUBMITTER: Vidal E 

PROVIDER: S-EPMC4107177 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature