Prostate cancer risk alleles are associated with prostate cancer volume and prostate size.

ABSTRACT:

Purpose

Genome-wide association studies have identified an increasing number of single nucleotide polymorphisms associated with prostate cancer risk. Some of these genetic variants are also associated with serum prostate specific antigen levels and lower urinary tract symptoms, raising the question of whether they are truly prostate cancer biomarkers or simply lead to detection bias. Therefore, we determined whether single nucleotide polymorphisms associated with prostate cancer risk are more strongly associated with tumor or prostate volume.

Materials and methods

The genotypes of 38 validated prostate cancer risk single nucleotide polymorphisms were determined in 1,321 white men who underwent radical prostatectomy. Univariate and multivariate analyses were performed to comp

SUBMITTER: Reinhardt D 

PROVIDER: S-EPMC4107200 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature