Hair metabolomics: identification of fetal compromise provides proof of concept for biomarker discovery.

ABSTRACT: Analysis of the human metabolome has yielded valuable insights into health, disease and toxicity. However, the metabolic profile of complex biological fluids such as blood is highly dynamic and this has limited the discovery of robust biomarkers. Hair grows relatively slowly, and both endogenous compounds and environmental exposures are incorporated from blood into hair during growth, which reflects the average chemical composition over several months. We used hair samples to study the metabolite profiles of women with pregnancies complicated by fetal growth restriction (FGR) and healthy matched controls. We report the use of GC-MS metabolite profiling of hair samples for biomarker discovery. Unsupervised statistical analysis showed complete discrimination of FGR from controls based on hai

SUBMITTER: Sulek K 

PROVIDER: S-EPMC4107295 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature