Brooding rumination and heart rate variability in women at high and low risk for depression: group differences and moderation by COMT genotype.

ABSTRACT: There is growing evidence that rumination, perhaps specifically brooding rumination, is a core feature of depression and that it contributes to the development and maintenance of the disorder. A separate line of research has highlighted the role played by heart rate variability (HRV). Both brooding rumination and HRV appear to be driven by disruption in the same neural circuit, heightened amygdala reactivity combined with decreased prefrontal control, and both are highlighted in different units of analysis as reflecting the Research Domain Criteria (RDoC) construct of Loss. However, little is known about the relation among these variables. In the current study, we predicted that higher levels of brooding rumination would be associated with lower levels of HRV and that women at high risk fo

SUBMITTER: Woody ML 

PROVIDER: S-EPMC4107362 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature