Visual short-term memory deficits associated with GBA mutation and Parkinson's disease.

ABSTRACT: Individuals with mutation in the lysosomal enzyme glucocerebrosidase (GBA) gene are at significantly high risk of developing Parkinson's disease with cognitive deficit. We examined whether visual short-term memory impairments, long associated with patients with Parkinson's disease, are also present in GBA-positive individuals-both with and without Parkinson's disease. Precision of visual working memory was measured using a serial order task in which participants observed four bars, each of a different colour and orientation, presented sequentially at screen centre. Afterwards, they were asked to adjust a coloured probe bar's orientation to match the orientation of the bar of the same colour in the sequence. An additional attentional 'filtering' condition tested patients' ability to selecti

SUBMITTER: Zokaei N 

PROVIDER: S-EPMC4107740 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature