Oxycodone/Naloxone: role in chronic pain management, opioid-induced constipation, and abuse deterrence.

ABSTRACT: The use of opioids in the treatment of chronic pain is widespread; the prevalence of specific opioids varies from country to country and depends on product availability, national formulary systems, and provider preferences. Patients often receive opioids for legitimate treatment of pain conditions, but on the opposite side of the spectrum, nonmedical use of opioids is a significant public health concern. Opioids are associated with several side effects, and constipation is the most commonly reported and persistent symptom. Unlike some adverse effects associated with opioid use, tolerance does not develop to constipation. Opioid-induced constipation (OIC) is the most prevalent patient complaint associated with opioid use and has been associated with declines in various quality of life measu

SUBMITTER: DePriest AZ 

PROVIDER: S-EPMC4108020 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature