Mitochondrial DNA association study of type 2 diabetes with or without ischemic stroke in Taiwan.

ABSTRACT:

Background

The importance of mitochondrial DNA (mtDNA) polymorphism in the prediction of type 2 diabetes (T2D) in men and women is not well understood. We questioned whether mtDNA polymorphism, mitochondrial functions, age and gender influenced the occurrence of T2D with or without ischemic stroke (IS).

Methods

We first designed a matched case-control study of 373 T2D patients and 327 healthy unrelated individuals without history of IS. MtDNA haplogroups were determined on all participants using sequencing of the control region and relevant SNPs from the coding region. Mitochondria functional tests, systemic biochemical measurements and complete genomic mtDNA sequencing were further determined on 239 participants (73 healthy controls, 33 T2D with IS, 70 T2D only and 63 IS pa

SUBMITTER: Loo JH 

PROVIDER: S-EPMC4108081 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature