Argonaute 2 promotes myeloma angiogenesis via microRNA dysregulation.

ABSTRACT:

Background

Dysregulated microRNA (miRNA) expression contributes to cancer cell proliferation, apoptosis and angiogenesis. Angiogenesis is a hallmark of multiple myeloma (MM) development and progression. Argonaute 2 (AGO2) protein, a core component of the RNA-induced silencing complex (RISC), can directly bind to miRNAs and mediate target messenger RNA (mRNA) degradation. A previous study showed that AGO2 knockdown suppressed human umbilical vein endothelial cell (HUVEC) growth and tube formation. However, the roles and molecular mechanisms of AGO2-induced myeloma angiogenesis are not yet fully understood. The aim of this study was to characterize these roles and effects and their associated mechanisms.

Results

Supernatants from AGO2-overexpressing MM lines induced HUVEC migr

SUBMITTER: Wu S 

PROVIDER: S-EPMC4108130 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature