LPA rs10455872 polymorphism is associated with coronary lesions in Brazilian patients submitted to coronary angiography.

ABSTRACT:

Background

Polymorphisms in the LPA gene were associated with coronary artery disease (CAD). However, there are differences in the allelic frequencies, Lp(a) levels, and significant association with CAD according to ethnic groups. In this scenario, the main aim of this study was to assess the influence of the LPA polymorphisms on coronary lesions in Brazilian patients.

Methods

1,394 consecutive patients submitted to coronary angiography to study suggestive CAD and twenty coronary segments were scored. Genotyping for the LPA rs10455872 and rs3798220 polymorphisms were performed by high resolution melting analysis.

Results

The frequencies of the rs10455872 G and rs3798220 C variant alleles were 6.4% and 6.2%, respectively. LPA rs10455872 G variant allele was associated

SUBMITTER: Santos PC 

PROVIDER: S-EPMC4108154 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature