Neurons in the ventral striatum exhibit cell-type-specific representations of outcome during learning.

ABSTRACT: The ventromedial striatum (VMS) is a node in circuits underpinning both affect and reinforcement learning. The cellular bases of these functions and especially their potential linkages have been unclear. VMS cholinergic interneurons, however, have been singled out as being related both to affect and to reinforcement-based conditioning, raising the possibility that unique aspects of their signaling could account for these functions. Here we show that VMS tonically active neurons (TANs), including putative cholinergic interneurons, generate unique bidirectional outcome responses during reward-based learning, reporting both positive (reward) and negative (reward omission) outcomes when behavioral change is prompted by switches in reinforcement contingencies. VMS output neurons (SPNs), by cont

SUBMITTER: Atallah HE 

PROVIDER: S-EPMC4108162 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature