Functional role of phosphodiesterase 3 in cardiomyocyte apoptosis: implication in heart failure.

ABSTRACT:

Background

Myocyte apoptosis plays an important role in pathological cardiac remodeling and the progression of heart failure. cAMP signaling is crucial in the regulation of myocyte apoptosis and cardiac remodeling. Multiple cAMP-hydrolyzing phosphodiesterases (PDEs), such as PDE3 and PDE4, coexist in cardiomyocytes and elicit differential temporal/spatial regulation of cAMP signaling. However, the role of PDE3 and PDE4 in the regulation of cardiomyocyte apoptosis remains unclear. Although chronic treatment with PDE3 inhibitors increases mortality in patients with heart failure, the contribution of PDE3 expression/activity in heart failure is not well known.

Methods and results

In this study we report that PDE3A expression and activity were significantly reduced in human fail

SUBMITTER: Ding B 

PROVIDER: S-EPMC4108189 | biostudies-literature | 2005 May

REPOSITORIES: biostudies-literature