Disproportionate contribution of right middle lobe to emphysema and gas trapping on computed tomography.

ABSTRACT:

Rationale

Given that the diagnosis of chronic obstructive pulmonary disease (COPD) relies on demonstrating airflow limitation by spirometry, which is known to be poorly sensitive to early disease, and to regional differences in emphysema, we sought to evaluate individual lobar contributions to global spirometric measures.

Methods

Subjects with COPD were compared with smokers without airflow obstruction, and non-smokers. Emphysema (% low attenuation area, LAAinsp<-950 HU, at end-inspiration) and gas trapping (%LAAexp<-856 HU at end-expiration) on CT were quantified using density mask analyses for the whole lung and for individual lobes, and distribution across lobes and strength of correlation with spirometry were compared.

Results

The right middle lobe had the highest

SUBMITTER: Bhatt SP 

PROVIDER: S-EPMC4108372 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature