Cleavage of Histone 3 by Cathepsin D in the involuting mammary gland.

ABSTRACT: The post-lactational regression of mammary gland is a complex multi-step process designed to conserve the biological function of the gland for next pregnancy. This developmental stage is a biological intrigue with great relevance to breast cancer research, and thus has been the subject of intensive scrutiny. Multipronged studies (microarray, proteomics profiling, animal knock-out models) have provided a repertoire of genes critical to involution. However, the caveat of these approaches remains in their failure to reveal post-translational modification(s), an emerging and critical aspect of gene regulation in developmental processes and mammary gland remodeling. The massive surge in the lysosomal enzymes concurrent with the onset of involution has been known for decades, and considered esse

SUBMITTER: Khalkhali-Ellis Z 

PROVIDER: S-EPMC4108390 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature