Electrophysiological and structural remodeling in heart failure modulate arrhythmogenesis. 2D simulation study.

ABSTRACT:

Background

Heart failure is operationally defined as the inability of the heart to maintain blood flow to meet the needs of the body and it is the final common pathway of various cardiac pathologies. Electrophysiological remodeling, intercellular uncoupling and a pro-fibrotic response have been identified as major arrhythmogenic factors in heart failure.

Objective

In this study we investigate vulnerability to reentry under heart failure conditions by incorporating established electrophysiological and anatomical remodeling using computer simulations.

Methods

The electrical activity of human transmural ventricular tissue (5 cm × 5 cm) was simulated using the human ventricular action potential model Grandi et al. under control and heart failure conditions. The MacCannell

SUBMITTER: Gomez JF 

PROVIDER: S-EPMC4108391 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature