Effects of increased image noise on image quality and quantitative interpretation in brain CT perfusion.

ABSTRACT:

Background and purpose

There is a desire within many institutions to reduce the radiation dose in CTP examinations. The purpose of this study was to simulate dose reduction through the addition of noise in brain CT perfusion examinations and to determine the subsequent effects on quality and quantitative interpretation.

Materials and methods

A total of 22 consecutive reference CTP scans were identified from an institutional review board-approved prospective clinical trial, all performed at 80 keV and 190 mAs. Lower-dose scans at 188, 177, 167, 127, and 44 mAs were generated through the addition of spatially correlated noise to the reference scans. A standard software package was used to generate CBF, CBV, and MTT maps. Six blinded radiologists determined quality scores of si

SUBMITTER: Juluru K 

PROVIDER: S-EPMC4108445 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature