Ron receptor-dependent gene regulation of Kupffer cells during endotoxemia.

ABSTRACT:

Background

Ron receptor tyrosine kinase signaling in macrophages, including Kupffer cells and alveolar macrophages, suppresses endotoxin-induced proinflammatory cytokine/chemokine production. Further, we have also identified genes from Ron replete and Ron deplete livers that were differentially expressed during the progression of liver inflammation associated with acute liver failure in mice by microarray analyses. While important genes and signaling pathways have been identified downstream of Ron signaling during progression of inflammation by this approach, the precise role that Ron receptor plays in regulating the transcriptional landscape in macrophages, and particular in isolated Kupffer cells, has still not been investigated.

Methods

Kupffer cells were isolated from wi

SUBMITTER: Kulkarni RM 

PROVIDER: S-EPMC4108450 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature