The association of duration of type 2 diabetes with cognitive performance is modulated by long-term glycemic control.

ABSTRACT:

Objectives

It is unclear why duration of type 2 diabetes (T2D) is associated with increased cognitive compromise. High hemoglobin A1c (HbA1c) has also been associated with dementia, and is the primary contributor to T2D complications. Here we investigated whether the association of duration of T2D with cognitive functioning is modulated by HbA1C levels.

Methods

This study examined nondemented community-dwelling T2D elderly (N = 897) participating in the Israel Diabetes and Cognitive Decline study, who were assessed with a broad neuropsychological battery. Subjects were all from the Maccabi Healthcare Services, which has a Diabetes Registry with complete HbA1c measurements since 1998. Partial correlations were performed to examine the modulating effect of HbA1c on the relatio

SUBMITTER: West RK 

PROVIDER: S-EPMC4108577 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature