Alcohol consumption mediates the relationship between ADH1B and DSM-IV alcohol use disorder and criteria.

ABSTRACT:

Objective

A single nucleotide variation in the alcohol dehydrogenase 1B (ADH1B) gene, rs1229984, produces an ADH1B enzyme with faster acetaldehyde production. This protective variant is associated with lower alcohol consumption and lower risk for alcohol use disorders (AUDs). Based on the premise that faster ADH1B kinetics decreases alcohol consumption, we formally tested if the association between ADH1B variant rs1229984 and AUDs occurs through consumption. We also tested whether the association between rs1229984 and each of the 11 Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV), AUD criteria occurs through consumption.

Method

A total of 1,130 lifetime drinkers from an Israeli household sample were assessed with a structured interview and geno

SUBMITTER: Kilcoyne B 

PROVIDER: S-EPMC4108604 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature