IRS-2 G1057D polymorphism in Turkish patients with colorectal cancer.

ABSTRACT:

Introduction

Gene polymorphisms have a broad range of analysis, but are of particular use in molecular medicine due to their potential in revealing the genetic tendency in diseases such as cancer, heart attack etc. These studies basically depend on mutations that can be detected by proper techniques. The genes coding the insulin receptor substrate (IRS) proteins are among the most widely analysed polymorphisms in various cancer types, in which a G1057D mutation is seen.

Aim

To determine the risk of colon cancer by analysing the IRS-2 gene polymorphism in Turkish patients.

Material and methods

A total of 161 newly diagnosed colorectal cancer patients were analysed and compared to 197 unrelated healthy controls. A polymerase chain reaction-based restriction fragment len

SUBMITTER: Yukseloglu EH 

PROVIDER: S-EPMC4108750 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature