Relationship of vitamin D binding protein polymorphisms and lung function in Korean chronic obstructive pulmonary disease.

ABSTRACT:

Purpose

Multiple genetic factors are associated with chronic obstructive pulmonary disease (COPD). The association of gene encoding vitamin D binding protein (VDBP, GC) with COPD has been controversial. We sought to investigate the types of GC variants in the Korean population and determine the association of GC variants with COPD and lung function in the Korean population.

Materials and methods

The study cohort consisted of 203 COPD patients and 157 control subjects. GC variants were genotyped by the restriction fragment-length polymorphism method. Repeated measures of lung function data were analyzed using a linear mixed model including sex, age, height, and pack-years of smoking to investigate the association of GC genetic factors and lung function.

Results

GC1F va

SUBMITTER: Jung JY 

PROVIDER: S-EPMC4108818 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature