Safety and efficacy of conversion from twice-daily tacrolimus to once-daily tacrolimus one month after transplantation: randomized controlled trial in adult renal transplantation.

ABSTRACT:

Purpose

The purpose of this study was to compare once-daily tacrolimus with twice-daily tacrolimus in terms of safety, efficacy, and patient satisfaction.

Materials and methods

This prospective, randomized, open-label, multicenter study was conducted at three institutes. Patients in the investigational group were converted from tacrolimus twice daily to the same dose of extended-release tacrolimus once daily at 1 month post-transplantation, while patients in the control group were maintained on tacrolimus twice daily. The efficacies, safeties, and patient satisfaction for the two drugs at 6 months post-transplantation were compared.

Results

Sixty patients were enrolled and randomized to the investigational group (28 of 29 patients completed the study) or the control g

SUBMITTER: Oh CK 

PROVIDER: S-EPMC4108821 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature