Seeking genetic signature of radiosensitivity--a novel method for data analysis in case of small sample sizes.

ABSTRACT:

Background

The identification of polymorphisms and/or genes responsible for an organism's radiosensitivity increases the knowledge about the cell cycle and the mechanism of the phenomena themselves, possibly providing the researchers with a better understanding of the process of carcinogenesis.

Aim

The aim of the study was to develop a data analysis strategy capable of discovering the genetic background of radiosensitivity in the case of small sample size studies.

Results

Among many indirect measures of radiosensitivity known, the level of radiation-induced chromosomal aberrations was used in the study. Mathematical modelling allowed the transformation of the yield-time curve of radiation-induced chromosomal aberrations into the exponential curve with limited number o

SUBMITTER: Zyla J 

PROVIDER: S-EPMC4108879 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature