Preserving sequence annotations across reference sequences.

ABSTRACT:

Background

Matching and comparing sequence annotations of different reference sequences is vital to genomics research, yet many annotation formats do not specify the reference sequence types or versions used. This makes the integration of annotations from different sources difficult and error prone.

Results

As part of our effort to create linked data for interoperable sequence annotations, we present an RDF data model for sequence annotation using the ontological framework established by the OBO Foundry ontologies and the Basic Formal Ontology (BFO). We defined reference sequences as the common domain of integration for sequence annotations, and identified three semantic relationships between sequence annotations. In doing so, we created the Reference Sequence Annotation to

SUBMITTER: Tatum Z 

PROVIDER: S-EPMC4108922 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature