The influence of different cellular environments on PET radioligand binding: an application to D2/3-dopamine receptor imaging.

ABSTRACT: Various D2/3 receptor PET radioligands are sensitive to endogenous dopamine release in vivo. The Occupancy Model is generally used to interpret changes in binding observed in in vivo competition binding studies; an Internalisation Hypothesis may also contribute to these changes in signal. Extension of in vivo competition imaging to other receptor systems has been relatively unsuccessful. A greater understanding of the cellular processes underlying signal changes following endogenous neurotransmitter release may help translate this imaging paradigm to other receptor systems. To investigate the Internalisation Hypothesis we assessed the effects of different cellular environments, representative of those experienced by a receptor following agonist-induced internalisation, on the binding of th

SUBMITTER: Quelch DR 

PROVIDER: S-EPMC4109028 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature