Novel dose-dependent alterations in excitatory GABA during embryonic development associated with lead (Pb) neurotoxicity.

ABSTRACT: Lead (Pb) is a heavy metal that is toxic to numerous physiological processes. Its use in industrial applications is widespread and results in an increased risk of human environmental exposure. The central nervous system (CNS) is most sensitive to Pb exposure during early development due to rapid cell proliferation and migration, axonal growth, and synaptogenesis. One of the key components of CNS development is the Gamma-aminobutyric acid (GABA)-ergic system. GABA is the primary inhibitory neurotransmitter in the adult brain. However, during development GABA acts as an excitatory neurotrophic factor which contributes to these cellular processes. Multiple studies report effects of Pb on GABA in the mature brain; however, little is known regarding the adverse effects of Pb exposure on the GAB

SUBMITTER: Wirbisky SE 

PROVIDER: S-EPMC4109047 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature