Novel functional changes during podocyte differentiation: increase of oxidative resistance and H-ferritin expression.

ABSTRACT: Podocytes are highly specialized, arborized epithelial cells covering the outer surface of the glomerular tuft in the kidney. Terminally differentiated podocytes are unable to go through cell division and hereby they are lacking a key property for regeneration after a toxic injury. Podocytes are long-lived cells but, to date, little is known about the mechanisms that support their stress resistance. Our aim was to investigate whether the well-known morphological changes during podocyte differentiation are accompanied by changes in oxidative resistance in a manner that could support their long-term survival. We used a conditionally immortalized human podocyte cell line to study the morphological and functional changes during differentiation. We followed the differentiation process for 14 da

SUBMITTER: Banyai E 

PROVIDER: S-EPMC4109136 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature