Identification of biomarkers for tuberculosis susceptibility via integrated analysis of gene expression and longitudinal clinical data.

ABSTRACT: Tuberculosis (TB) is an infectious disease caused by the bacteria Mycobacterium tuberculosis (Mtb) that affects millions of people worldwide. The majority of individuals who are exposed to Mtb develop latent infections, in which an immunological response to Mtb antigens is present but there is no clinical evidence of disease. Because currently available tests cannot differentiate latent individuals who are at low risk from those who are highly susceptible to developing active disease, there is considerable interest in the identification of diagnostic biomarkers that can predict reactivation of latent TB. We present results from our analysis of a controlled longitudinal experiment in which a group of rhesus macaques were exposed to a low dose of Mtb to study their progression to latent infe

SUBMITTER: Luo Q 

PROVIDER: S-EPMC4109430 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature