The TRHR Gene Is Associated with Hypothalamo-Pituitary Sensitivity to Levothyroxine.

ABSTRACT:

Background

Thyroidectomized patients need variable doses of levothyroxine (LT4) to obtain target thyroid-stimulating hormone (TSH) levels. Individual feedback set-points have been hypothesized and the influence of several genes in the regulation of the pituitary-thyroid axis has been demonstrated.

Objectives

We hypothesized that genetic variants of the TRHR gene could be associated with a different hypothalamo-pituitary sensitivity to thyroid hormone feedback.

Methods

We retrospectively analyzed 84 thyroidectomized patients with no residual thyroid function and undetectable thyroglobulin levels. Patients were evaluated under LT4 resulting in TSH levels detectable but <0.5 μIU/ml. The two SNPs rs3134105 and rs3110040 were identified as informative markers of the TRHR g

SUBMITTER: Brigante G 

PROVIDER: S-EPMC4109513 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature