Estimation of input functions from dynamic [18F]FLT PET studies of the head and neck with correction for partial volume effects.

ABSTRACT:

Background

We present a method for extracting arterial input functions from dynamic [18F]FLT PET images of the head and neck, directly accounting for the partial volume effect. The method uses two blood samples, for which the optimum collection times are assessed.

Methods

Six datasets comprising dynamic PET images, co-registered computed tomography (CT) scans and blood-sampled input functions were collected from four patients with head and neck tumours. In each PET image set, a region was identified that comprised the carotid artery (outlined on CT images) and surrounding tissue within the voxels containing the artery. The time course of activity in the region was modelled as the sum of the blood-sampled input function and a compartmental model of tracer uptake in the surrou

SUBMITTER: Hackett SL 

PROVIDER: S-EPMC4109699 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature