Neural responses during social reflection in relatives of schizophrenia patients: relationship to subclinical delusions.

ABSTRACT:

Background

Deficits in the capacity to reflect about the self and others ("social reflection" [SR]) have been identified in schizophrenia, as well as in people with a genetic or clinical risk for the disorder. However, the neural underpinnings of these abnormalities are incompletely understood.

Methods

Responses of a network of brain regions known to be involved in self and other processing (e.g., medial prefrontal cortex (MPFC), posterior cingulate cortex (PCC), and superior temporal gyrus (STG)) were measured during SR in 16 first-degree, non-psychotic relatives (RELS) of schizophrenia patients and 16 healthy controls (CONS). Because of prior evidence linking dysfunction in this network and delusions, associations between SR-related responses of this network and subclinica

SUBMITTER: Brent BK 

PROVIDER: S-EPMC4109724 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature