A very low incidence of BRAF mutations in Middle Eastern colorectal carcinoma.

ABSTRACT:

Background

Recent studies emphasize the role of BRAF as a genetic marker for prediction, prognosis and risk stratification in colorectal cancer. Earlier studies have reported the incidence of BRAF mutations in the range of 5-20% in colorectal carcinomas (CRC) and are predominantly seen in the serrated adenoma-carcinoma pathway characterized by microsatellite instability (MSI-H) and hypermethylation of the MLH1 gene in the setting of the CpG island methylator phenotype (CIMP). Due to the lack of data on the true incidence of BRAF mutations in Saudi Arabia, we sought to analyze the incidence of BRAF mutations in this ethnic group.

Methods

770 CRC cases were analyzed for BRAF and KRAS mutations by direct DNA sequencing.

Results

BRAF gene mutations were seen in 2.5% (19/7

SUBMITTER: Siraj AK 

PROVIDER: S-EPMC4109832 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature