Abnormal oxidative stress responses in fibroblasts from preeclampsia infants.

ABSTRACT:

Background

Signs of severe oxidative stress are evident in term placentae of infants born to mothers with preeclampsia (PE), but it is unclear whether this is a cause or consequence of the disease. Here fibroblast lines were established from umbilical cords (UC) delivered by mothers who had experienced early onset PE and from controls with the goal of converting these primary cells to induced pluripotent stem cells and ultimately trophoblast. Contrary to expectations, the oxidative stress responses of these non-placental cells from PE infants were more severe than those from controls.

Methods and findings

Three features suggested that UC-derived fibroblasts from PE infants responded less well to oxidative stressors than controls: 1) While all UC provided outgrowths in 4% O2,

SUBMITTER: Yang P 

PROVIDER: S-EPMC4110005 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature