Estimated albumin excretion rate versus urine albumin-creatinine ratio for the assessment of albuminuria: a diagnostic test study from the Prevention of Renal and Vascular Endstage Disease (PREVEND) Study.

ABSTRACT:

Background

Albumin-creatinine ratio (ACR) in spot urine samples is recommended for albuminuria screening instead of measured albumin excretion rate (mAER) in 24-hour urine collections. In patients with extremes of muscle mass, differences in spot urine creatinine values may lead to under- or overestimation of mAER by ACR. We hypothesized that calculating estimated AER (eAER) using spot ACR and estimated creatinine excretion rate (eCER) may improve albuminuria assessment.

Study design

Diagnostic test study.

Setting & participants

2,711 community-living individuals from the general population of the Netherlands participating in the PREVEND (Prevention of Renal and Vascular Endstage Disease) Study.

Index test

eAER was computed as the product of ACR and eCER. eCER

SUBMITTER: Abdelmalek JA 

PROVIDER: S-EPMC4110052 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature