Long noncoding RNA in liver diseases.

ABSTRACT:

Unlabelled

The identification of the presence of large RNA transcripts that do not code for proteins but that may have biological functions has provided an important new perspective in gene regulation. These long noncoding RNAs (lncRNAs) are being increasingly recognized to contribute to many biological processes through diverse mechanisms. The roles of these emerging genes are being recognized across kingdoms. These findings are profoundly altering our understanding of disease pathobiology and leading to the emergence of new biological concepts underlying human diseases. Strategies for the discovery and characterization of lncRNAs are highlighted. Several lncRNAs have been described in liver disease, and in liver cancers in particular. Their molecular mechanisms of action, functio

SUBMITTER: Takahashi K 

PROVIDER: S-EPMC4110118 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature