Effect of fluconazole prophylaxis on candidiasis and mortality in premature infants: a randomized clinical trial.

ABSTRACT:

Importance

Invasive candidiasis in premature infants causes death and neurodevelopmental impairment. Fluconazole prophylaxis reduces candidiasis, but its effect on mortality and the safety of fluconazole are unknown.

Objective

To evaluate the efficacy and safety of fluconazole in preventing death or invasive candidiasis in extremely low-birth-weight infants.

Design, setting, and patients

This study was a randomized, blinded, placebo-controlled trial of fluconazole in premature infants. Infants weighing less than 750 g at birth (N = 361) from 32 neonatal intensive care units (NICUs) in the United States were randomly assigned to receive either fluconazole or placebo twice weekly for 42 days. Surviving infants were evaluated at 18 to 22 months corrected age for neurodev

SUBMITTER: Benjamin DK 

PROVIDER: S-EPMC4110724 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature