Ontology highlight
ABSTRACT:
SUBMITTER: Rimmele P
PROVIDER: S-EPMC4110778 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Stem cell reports 20140606 1
Aging hematopoietic stem cells (HSCs) exhibit defective lineage specification that is thought to be central to increased incidence of myeloid malignancies and compromised immune competence in the elderly. Mechanisms underlying these age-related defects remain largely unknown. We show that the deacetylase Sirtuin (SIRT)1 is required for homeostatic HSC maintenance. Differentiation of young SIRT1-deleted HSCs is skewed toward myeloid lineage associated with a significant decline in the lymphoid co ...[more]