Common PTP4A1-PHF3-EYS variants are specific for alcohol dependence.

ABSTRACT:

Background and objectives

We previously reported a risk genomic region (ie, PTP4A1-PHF3-EYS) for alcohol dependence in a genome-wide association study (GWAS). We also reported a rare variant constellation across this region that was significantly associated with alcohol dependence. In the present study, we significantly increased the marker density within this region and examined the specificity of the associations of common variants for alcohol dependence.

Methods

One African-American discovery sample (681 cases with alcohol dependence and 508 controls), one European-American replication sample (1,409 alcohol dependent cases and 1,518 controls), and one European-Australian replication sample (a total of 6,438 family subjects with 1,645 alcohol dependent probands) underwent

SUBMITTER: Zuo L 

PROVIDER: S-EPMC4111256 | biostudies-literature | 2014 Jul-Aug

REPOSITORIES: biostudies-literature