In vivo skin penetration of quantum dot nanoparticles in the murine model: the effect of UVR.

ABSTRACT: Ultraviolet radiation (UVR) has widespread effects on the biology and integrity of the skin barrier. Research on the mechanisms that drive these changes, as well as their effect on skin barrier function, has been ongoing since the 1980s. However, no studies have examined the impact of UVR on nanoparticle skin penetration. Nanoparticles (NP) are commonly used in sunscreens and other cosmetics, and since consumer use of sunscreen is often applied to sun damaged skin, the effect of UVR on NP skin penetration is a concern due to potential toxicity. In this study, we investigate NP skin penetration by employing an in vivo semiconductor quantum dot nanoparticle (QD) model system. This model system improves NP imaging capabilities and provides additional primary interest due to widespread and exp

SUBMITTER: Mortensen LJ 

PROVIDER: S-EPMC4111258 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature