Variants of asthma and chronic obstructive pulmonary disease genes and lung function decline in aging.

ABSTRACT:

Background

A substantial proportion of the general population has low lung function, and lung function is known to decrease as we age. Low lung function is a feature of several pulmonary disorders, such as uncontrolled asthma and chronic obstructive pulmonary disease. The objective of this study is to investigate the association of polymorphisms in asthma and chronic obstructive pulmonary disease candidate genes with rates of lung function decline in a general population sample of aging men.

Methods

We analyzed data from a cohort of 1,047 Caucasian men without known lung disease, who had a mean of 25 years of lung function data, and on whom DNA was available. The cohort was randomly divided into two groups, and we tested a total of 940 single-nucleotide polymorphisms in 44 a

SUBMITTER: Poon AH 

PROVIDER: S-EPMC4111635 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature