Cone structure in subjects with known genetic relative risk for AMD.

ABSTRACT:

Purpose

Utilize high-resolution imaging to examine retinal anatomy in patients with known genetic relative risk (RR) for developing age-related macular degeneration (AMD).

Methods

Forty asymptomatic subjects were recruited (9 men, 31 women; age range, 51 to 69 years; mean age, 61.4 years). Comprehensive eye examination, fundus photography, and high-resolution retinal imaging using spectral domain optical coherence tomography and adaptive optics were performed on each patient. Genetic RR scores were developed using an age-independent algorithm. Adaptive optics scanning light ophthalmoscope images were acquired in the macula extending to 10 degrees temporal and superior from fixation and were used to calculate cone density in up to 35 locations for each subject.

Results

SUBMITTER: Land ME 

PROVIDER: S-EPMC4111779 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature