Evolutionarily conserved prefrontal-amygdalar dysfunction in early-life anxiety.

ABSTRACT: Some individuals are endowed with a biology that renders them more reactive to novelty and potential threat. When extreme, this anxious temperament (AT) confers elevated risk for the development of anxiety, depression and substance abuse. These disorders are highly prevalent, debilitating and can be challenging to treat. The high-risk AT phenotype is expressed similarly in children and young monkeys and mechanistic work demonstrates that the central (Ce) nucleus of the amygdala is an important substrate. Although it is widely believed that the flow of information across the structural network connecting the Ce nucleus to other brain regions underlies primates' capacity for flexibly regulating anxiety, the functional architecture of this network has remained poorly understood. Here we used

SUBMITTER: Birn RM 

PROVIDER: S-EPMC4111803 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature