Measles vaccination in the presence or absence of maternal measles antibody: impact on child survival.

ABSTRACT:

Background

Measles vaccine (MV) has a greater effect on child survival when administered in early infancy, when maternal antibody may still be present.

Methods

To test whether MV has a greater effect on overall survival if given in the presence of maternal measles antibody, we reanalyzed data from 2 previously published randomized trials of a 2-dose schedule with MV given at 4-6 months and at 9 months of age. In both trials antibody levels had been measured before early measles vaccination.

Results

In trial I (1993-1995), the mortality rate was 0.0 per 1000 person-years among children vaccinated with MV in the presence of maternal antibody and 32.3 per 1000 person-years without maternal antibody (mortality rate ratio [MRR], 0.0; 95% confidence interval [CI], 0-.52). I

SUBMITTER: Aaby P 

PROVIDER: S-EPMC4111916 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature