Respiratory outcomes of the surfactant positive pressure and oximetry randomized trial (SUPPORT).

ABSTRACT:

Objective

To explore the early childhood pulmonary outcomes of infants who participated in the National Institute of Child Health and Human Development's Surfactant Positive Airway Pressure and Pulse Oximetry Randomized Trial (SUPPORT), using a factorial design that randomized extremely preterm infants to lower vs higher oxygen saturation targets and delivery room continuous positive airway pressure (CPAP) vs intubation/surfactant.

Study design

The Breathing Outcomes Study, a prospective secondary study to the Surfactant Positive Airway Pressure and Pulse Oximetry Randomized Trial, assessed respiratory morbidity at 6-month intervals from hospital discharge to 18-22 months corrected age (CA). Two prespecified primary outcomes-wheezing more than twice per week during the worst

SUBMITTER: Stevens TP 

PROVIDER: S-EPMC4111960 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature