Characterization of nanoparticle delivery in microcirculation using a microfluidic device.

ABSTRACT: This work focuses on the characterization of particle delivery in microcirculation through a microfluidic device. In microvasculature the vessel size is comparable to that of red blood cells (RBCs) and the existence of blood cells largely influences the dispersion and binding distribution of drug loaded particles. The geometry of the microvasculature leads to non-uniform particle distribution and affects the particle binding characteristics. We perform an in vitro study in a microfluidic chip with micro vessel mimicking channels having a rectangular cross section. Various factors that influence particle distribution and delivery such as the vessel geometry, shear rate, blood cells, particle size, particle antibody density are considered in this study. Around 10% higher particle binding den

SUBMITTER: Thomas A 

PROVIDER: S-EPMC4111996 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature