White matter correlates of adolescent depression: structural evidence for frontolimbic disconnectivity.

ABSTRACT:

Objective

Despite the significant prevalence of adolescent depression, little is known about the neuroanatomical basis of this disorder. Functional dysregulation in frontolimbic circuitry has been suggested as a key neural correlate of adult and adolescent depression impeding emotional regulation. However, less is known about whether this dysregulation is overlaid on impaired white matter microstructure. Guided by neuroimaging findings, we test the a priori hypotheses that adolescent depression is associated with alterations in white matter microstructure in the uncinate fasciculus (UF) and cingulum bundles.

Method

Diffusion tensor magnetic resonance imaging (DTI) data were obtained on 52 unmedicated adolescents with major depressive disorder (MDD) and 42 matched controls. W

SUBMITTER: LeWinn KZ 

PROVIDER: S-EPMC4112055 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature