Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants.

ABSTRACT:

Background and purpose

Ischemic stroke (IS) and coronary artery disease (CAD) share several risk factors and each has a substantial heritability. We conducted a genome-wide analysis to evaluate the extent of shared genetic determination of the two diseases.

Methods

Genome-wide association data were obtained from the METASTROKE, Coronary Artery Disease Genome-wide Replication and Meta-analysis (CARDIoGRAM), and Coronary Artery Disease (C4D) Genetics consortia. We first analyzed common variants reaching a nominal threshold of significance (P<0.01) for CAD for their association with IS and vice versa. We then examined specific overlap across phenotypes for variants that reached a high threshold of significance. Finally, we conducted a joint meta-analysis on the combined phenoty

SUBMITTER: Dichgans M 

PROVIDER: S-EPMC4112102 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature