TFAP2C governs the luminal epithelial phenotype in mammary development and carcinogenesis.

ABSTRACT: Molecular subtypes of breast cancer are characterized by distinct patterns of gene expression that are predictive of outcome and response to therapy. The luminal breast cancer subtypes are defined by the expression of estrogen receptor-alpha (ERα)-associated genes, many of which are directly responsive to the transcription factor activator protein 2C (TFAP2C). TFAP2C participates in a gene regulatory network controlling cell growth and differentiation during ectodermal development and regulating ESR1/ERα and other luminal cell-associated genes in breast cancer. TFAP2C has been established as a prognostic factor in human breast cancer, however, its role in the establishment and maintenance of the luminal cell phenotype during carcinogenesis and mammary gland development have remained elusiv

SUBMITTER: Cyr AR 

PROVIDER: S-EPMC4112181 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature