Transcriptome-wide analysis of microRNA expression in the malaria mosquito Anopheles gambiae.

ABSTRACT:

Background

microRNAs (miRNAs) are a highly abundant class of small noncoding regulatory RNAs that post-transcriptionally regulate gene expression in multicellular organisms. miRNAs are involved in a wide range of biological and physiological processes, including the regulation of host immune responses to microbial infections. Small-scale studies of miRNA expression in the malaria mosquito Anopheles gambiae have been reported, however no comprehensive analysis of miRNAs has been performed so far.

Results

Using small RNA sequencing, we characterized de novo A. gambiae miRNA repertoire expressed in adult sugar- and blood-fed females. We provided transcriptional evidences for 123 miRNAs, including 58 newly identified miRNAs. Out of the newly described miRNAs, 19 miRNAs are homol

SUBMITTER: Biryukova I 

PROVIDER: S-EPMC4112208 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature