Genetic predictors associated with improvement of asthma symptoms in response to inhaled corticosteroids.

ABSTRACT:

Background

To date, genome-wide association studies (GWASs) of inhaled corticosteroid (ICS) response in asthmatic patients have focused primarily on lung function and exacerbations.

Objective

We hypothesized that GWAS analysis could identify novel genetic markers predicting a symptomatic response to ICSs.

Methods

We analyzed differences in asthma symptoms in response to ICSs in 124 white children from the Childhood Asthma Management Program (CAMP) trial using scores from diary cards. Of the 440,862 single nucleotide polymorphisms (SNPs) analyzed, the top 100 ranked SNPs were pursued for replication initially in subjects from the pediatric Childhood Asthma Research and Education trials (77 white children) and then in subjects from the adult Asthma Clinical Research Net

SUBMITTER: Park HW 

PROVIDER: S-EPMC4112383 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature